Job Description

Post Doctoral Positions in Biological and Translational Proteomics

The highly interdisciplinary and collaborative proteomics group at the Broad Institute of MIT and Harvard is looking for strongly motivated post-doctoral associates with relevant experience to step into exciting, highly visible and impactful roles in internationally-recognized efforts to 1) develop and apply state-of-the art proteomics technologies to address important and translatable questions in biology and clinical medicine or 2) lead data analysis and interpretation in projects that leverage the vast amount of multiomic and proteogenomic data that is generated by the group. Successful candidates would have the immediate opportunity to contribute to one of more of the following areas:

• Drive multiomic and proteogenomic studies in cancer, metabolic disease and neurological disorders to gain biological insights and identify new therapeutic vulnerabilities
• Deepen understanding of immune biology with implications for enhancing immunotherapy
• Define the landscape and function of cellular signaling networks modulated by protein phosphorylation, ubiquitylation, acetylation (PTMs) and their cross-talk
• Elucidate mechanisms of response and resistance to therapy
• Develop and optimize new, broadly enabling proteomic technologies
• Employ spatial proteomics methods for understanding heterogeneity
• Identify candidate diagnostic and predictive markers of disease presence and stage using MS and non-MS based methods

Successful candidates will work as part of an interdisciplinary team of clinicians, biologists, computational and proteomics scientists at the Broad and with an international group of renowned partner institutions to deeply characterize and understand the proteomes, PTM-omes and metabolomes of soft tissues, cells and biofluids.

Candidates must have:

• an MD or Ph.D. in biology, biochemistry, or a closely related field
• excellent scientific productivity, evidenced by high-quality research publications in peer reviewed journals
• a track record of conducting independent and creative research
• excellent verbal and written communication skills

Practical skills and knowledge are required in one or more of the following areas:

• state-of-the-art mass spectrometry-based proteomics
• statistical and/or computational analysis of large-scale proteomic or genomic data
• analysis of cell signaling pathways/networks
• cell biology/ biochemical methods to understand protein function
• molecular biology/CRISPR-based genome editing

The Broad Institute is a world-leading non-profit research organization dedicated to realizing the promise of the post-genomic era for human benefit. Located in Cambridge, MA with strong ties to MIT, Harvard, and world class Boston hospitals, the Broad Institute brings together scientists of diverse backgrounds to solve critical problems in biology and medicine in an interdisciplinary manner. The Broad Institute, and the embedded Proteomics Group (www.broadinstitute.org/proteomics), have an outstanding track-record in training the next generation of research scientists and in developing and applying proteomic technologies critical to address important questions in biology and medicine. We collaborate with top-level researchers throughout the world, and results of these studies and our technology developments are published in top-tier journals.

Interested scientists are encouraged to apply on-line at the Broad Website. Inquiries can also be addressed to Dr. Steven Carr, Sr. Director of Proteomics, Broad Institute (scarr@broad.mit.edu) and Namrata Udeshi, Associate Director of Proteomics (Udeshi@broadinstitute.org) or jobs-proteomics@broadinstitute.org.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.